Last reviewed: September 22, 2025 What this article covers: why the psychedelic facilitator–client relationship is often more important than the medicine itself, what training and qualities matter most, how cultural fit shapes outcomes, and how seekers can evaluate...
FDA Publishes MDMA CRL, Exposes Safety and Durability Concerns for Psychedelic Therapies The US Food and Drug Administration announced on September 4, 2025 that it will publish Complete Response Letters promptly after they are issued, and it released a batch of 89...
Why this matters: Microdosing psychedelics has grown from subculture practice to mainstream wellness trend, but rigorous clinical evidence is sparse and safety signals are emerging. This explainer summarizes current gaps, recent concerns, and practical steps for...
Single dose of MM120 (LSD) shows lasting reduction in generalized anxiety disorder, JAMA reports Why this matters: A randomized, placebo-controlled Phase 2b trial published in JAMA found that a single oral dose of MM120, an investigational LSD formulation,...
Brian, a JourneyŌM guide reflects on presence, capacity, and the steady work of being human. It’s Supposed To Hurt… …at least some of the time. I’ve allowed this to partially sink in, against my will, kicking and screaming, over the past 10 years as my personal work...
In a quiet lab corner, something unexpected happened. Mice given psilocybin didn’t just survive longer—they seemed to age differently. According to new peer-reviewed research published in npj Aging, female rodents treated with psilocybin over time...
In recent years, ketamine therapy has emerged as one of the most promising tools in the psychedelic-assisted therapy landscape. Originally developed as an anesthetic, ketamine is now showing remarkable potential for conditions like depression, PTSD, and...
It starts innocently enough. You’re prepping for a solo psilocybin experience. You dim the lights, queue your playlist, and open an app that promises structured prompts, real-time check-ins, and therapeutic journaling support. No human needed. It’s like having a guide...
When Nico sat across from his psychiatrist after trying yet another antidepressant that didn’t work, he wasn’t angry—he was numb. Thirty years of depression had taught him to live in grayscale. Therapy, medications, even TMS had provided temporary relief, but...
Curious about psychedelic therapy but not sure who or what to trust? You’re not alone. From podcasts to documentaries, plant medicines like psilocybin and MDMA are showing up everywhere—and now, they’ve entered the political arena. In a recent AP article,...
