by Jean-Philippe Simon | May 27, 2026 | FDA, Legal, Legal / Policy / Geo-Legal, MDMA, Mental Health, PTSD, Science, Substance Deep-Dives, Therapy
The FDA rejected Lykos Therapeutics’ application for MDMA-assisted therapy for PTSD in August 2024, and as of mid-2026 that decision stands. MDMA remains a Schedule I substance in the United States, meaning the only legal access pathways are through active...
by Jean-Philippe Simon | May 11, 2026 | Couples, Executive, Integration, Journey, MDMA, Preparation, Preparation / Integration, Psychedelics, Therapy
Couples psychedelic therapy is an emerging clinical area with early but substantive evidence behind it. Professionally supported shared experiences using MDMA or psilocybin can reduce relational rigidity, improve communication, and address post-trauma dynamics. They...
by Jean-Philippe Simon | May 8, 2026 | Anxiety, Depression, Esketamine, FDA, Harm Reduction, Ketamine, MDMA, Mental Health, Preparation, Preparation / Integration, Psilocybin, Psychedelics, Science, Somatic, SSRI / SNRI, Therapy
Talking to your doctor about psychedelic therapy is one of the most common points where people get stuck. This guide walks you through how to frame the conversation, what questions to bring, and what to understand about medications like SSRIs before you book that...
by Nico | Apr 20, 2026 | Depression, FDA, Legal, MDMA, Mental Health, Neuroplasticity, Psilocybin, Psychedelics, PTSD, Science, Science & Research, Therapy, Veterans
Psilocybin PTSD therapy is no longer a fringe concept. A growing body of clinical research, including Phase 2 trials published in 2025, shows that a single guided dose can produce meaningful, lasting reductions in PTSD symptoms. The evidence is promising, but also...
by Nico | Nov 22, 2025 | FDA, Harm Reduction, Legal / Policy / Geo-Legal, MDMA, Mental Health, politics, Science, Therapy, Veterans
The FDA rejected Lykos Therapeutics’ application for MDMA-assisted therapy for PTSD, citing three specific concerns: gaps in safety reporting, insufficient evidence that benefits lasted over time, and questions about who was enrolled in the trials. The MDMA...
by Nico | Jul 17, 2025 | Guides, Harm Reduction, Integration, Interviews, Journey, MDMA, Mental Health, Personal Reflections, Preparation, Therapy
Psychedelic guide matching is one of the most important decisions a seeker can make, and at JourneyOM, it is never left to an algorithm. This post explains how JourneyOM’s concierge model works, why the match matters as much as the medicine, and what to expect...
