Microdosing for Depression and Anxiety: What the Clinical Evidence Actually Shows
Placebo-controlled trials of microdosing have consistently failed to show that low doses of psilocybin or LSD outperform placebo for mood, anxiety, or well-being. People taking a...
The Best Psychedelic for Depression? Psilocybin vs Ketamine vs LSD vs Ayahuasca
There is no single best psychedelic for depression, but the evidence is not evenly distributed. Ketamine has the strongest legal access and the fastest onset, psilocybin...
5-MeO-DMT for Depression and Anxiety: What the Evidence Shows
Research on 5-MeO-DMT for depression and anxiety, particularly in the context of 5-MeO-DMT depression anxiety treatment, is genuinely early, but it is no longer purely anecdotal....
Ayahuasca Depression Treatment: What the First Randomized Trial Showed
In 2019, Brazilian researchers published the first randomized placebo-controlled trial of a psychedelic in treatment-resistant depression, and it tested ayahuasca. Seven days after a single dose,...
LSD Depression Treatment: The Renewed Clinical Interest in Lysergic Acid
LSD depression treatment has moved from a decades-long research freeze into late-stage clinical trials, with a Phase 3 study of a pharmaceutical LSD formulation reporting positive...
LSD Therapy Guide: From Hofmann’s Discovery to Modern Clinical Use
LSD-assisted therapy uses a single high dose of lysergic acid diethylamide, given alongside structured psychological support, to treat anxiety and related conditions. Modern controlled trials, including...
Ketamine Therapy: A Complete Guide to Forms, Administration, and What to Expect | JourneyŌM
Ketamine therapy is delivered through several distinct routes, including intravenous infusion, intramuscular injection, FDA-approved esketamine nasal spray, and compounded sublingual or oral formulations. The route you...
Treatment-Resistant Depression and Psychedelic Therapy: How the Conversation Is Changing
Treatment-resistant depression psychedelic therapy refers to the use of compounds like psilocybin and ketamine for people whose depression has not responded to at least two standard...
Ketamine for Treatment-Resistant Depression: The Fastest-Acting Antidepressant
Ketamine for treatment-resistant depression can reduce symptoms within hours rather than the four to six weeks standard antidepressants typically require, and in a single large controlled...
Psilocybin Therapy Guide: A Complete Guide to Therapeutic Use
Psilocybin is the active compound in certain mushrooms, and in a therapeutic setting it is used in one or two carefully prepared sessions alongside professional psychological...
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