Ibogaine Therapy: A Complete Guide to the Most Powerful and Risky Psychedelic
Ibogaine is a plant-derived psychedelic with real promise for interrupting opioid addiction and, more recently, for treating trauma, but it carries a risk of fatal heart...
LSD Alcoholism Treatment: The Forgotten Research That Started Psychedelic Therapy
Six randomized controlled trials of LSD alcoholism treatment conducted between the 1950s and 1970s, pooled in a 2012 meta-analysis of 536 participants, found that a single...
5-MeO-DMT: A Complete Guide to One of the Most Intense Psychedelics
5-MeO-DMT is a fast-acting psychedelic found in the secretion of the Sonoran Desert toad and also made synthetically, known for producing near-total loss of ordinary awareness...
LSD Anxiety Treatment: What Modern Clinical Trials Are Finding
Research on LSD anxiety treatment has produced some of the strongest controlled data in psychedelic medicine. A 2025 Phase 2b trial published in JAMA found that...
Complex PTSD Psychedelic Therapy: Why cPTSD Is Different from PTSD
Complex PTSD (cPTSD) differs from PTSD because it develops from prolonged, repeated trauma, and it adds lasting disturbances in emotional regulation, self-worth, and relationships on top...
Ayahuasca: A Comprehensive Guide to the Experience, Risks, and Therapeutic Potential
Ayahuasca is a plant brew from the Amazon that combines DMT with monoamine oxidase inhibitors (MAOI), producing a long, often intense psychedelic experience used traditionally for...
MDMA Couples Therapy: When Shared Healing Requires Shared Vulnerability
MDMA couples therapy has been tested in only one published trial: a 2020 uncontrolled pilot of six couples that combined MDMA with Cognitive-Behavioural Conjoint Therapy for...
MDMA for Childhood Trauma: What the Research Shows About Healing Early Wounds
No clinical trial has yet tested MDMA-assisted therapy specifically for childhood trauma as a standalone diagnosis, so the real answer is that direct evidence does not...
LSD Therapy Guide: From Hofmann’s Discovery to Modern Clinical Use
LSD-assisted therapy uses a single high dose of lysergic acid diethylamide, given alongside structured psychological support, to treat anxiety and related conditions. Modern controlled trials, including...
MDMA for Sexual Trauma: How the Therapeutic Model Addresses Trust and Safety
MDMA-assisted therapy has strong Phase 3 evidence for PTSD generally, and sexual trauma survivors were well represented in those trials, but no published randomized trial has...
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