Ayahuasca Depression Treatment: What the First Randomized Trial Showed
In 2019, Brazilian researchers published the first randomized placebo-controlled trial of a psychedelic in treatment-resistant depression, and it tested ayahuasca. Seven days after a single dose,...
Childhood Trauma and Psychedelic Therapy: Healing Developmental Wounds in Adulthood
Childhood trauma is not a formal diagnosis, yet early and repeated adversity reshapes the developing brain and often surfaces decades later as depression, anxiety, or PTSD....
LSD Alcoholism Treatment: The Forgotten Research That Started Psychedelic Therapy
Six randomized controlled trials of LSD alcoholism treatment conducted between the 1950s and 1970s, pooled in a 2012 meta-analysis of 536 participants, found that a single...
LSD Depression Treatment: The Renewed Clinical Interest in Lysergic Acid
LSD depression treatment has moved from a decades-long research freeze into late-stage clinical trials, with a Phase 3 study of a pharmaceutical LSD formulation reporting positive...
LSD Anxiety Treatment: What Modern Clinical Trials Are Finding
Research on LSD anxiety treatment has produced some of the strongest controlled data in psychedelic medicine. A 2025 Phase 2b trial published in JAMA found that...
Complex PTSD Psychedelic Therapy: Why cPTSD Is Different from PTSD
Complex PTSD (cPTSD) differs from PTSD because it develops from prolonged, repeated trauma, and it adds lasting disturbances in emotional regulation, self-worth, and relationships on top...
MDMA for Childhood Trauma: What the Research Shows About Healing Early Wounds
No clinical trial has yet tested MDMA-assisted therapy specifically for childhood trauma as a standalone diagnosis, so the real answer is that direct evidence does not...
MDMA for Sexual Trauma: How the Therapeutic Model Addresses Trust and Safety
MDMA-assisted therapy has strong Phase 3 evidence for PTSD generally, and sexual trauma survivors were well represented in those trials, but no published randomized trial has...
PTSD Psychedelic Therapy: A Science-Based Overview
Among psychedelic approaches to PTSD, MDMA-assisted therapy has the strongest evidence, with two Phase 3 trials showing large symptom reductions, though the FDA declined to approve...
MDMA for Complex PTSD: Why Standard Treatments Fall Short
MDMA for complex PTSD has not been tested in a dedicated clinical trial, so no treatment can honestly claim proven results for this diagnosis. What we...
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