Ayahuasca Depression Treatment: What the First Randomized Trial Showed
In 2019, Brazilian researchers published the first randomized placebo-controlled trial of a psychedelic in treatment-resistant depression, and it tested ayahuasca. Seven days after a single dose,...
Childhood Trauma and Psychedelic Therapy: Healing Developmental Wounds in Adulthood
Childhood trauma is not a formal diagnosis, yet early and repeated adversity reshapes the developing brain and often surfaces decades later as depression, anxiety, or PTSD....
Ibogaine Therapy: A Complete Guide to the Most Powerful and Risky Psychedelic
Ibogaine is a plant-derived psychedelic with real promise for interrupting opioid addiction and, more recently, for treating trauma, but it carries a risk of fatal heart...
LSD Alcoholism Treatment: The Forgotten Research That Started Psychedelic Therapy
Six randomized controlled trials of LSD alcoholism treatment conducted between the 1950s and 1970s, pooled in a 2012 meta-analysis of 536 participants, found that a single...
LSD Depression Treatment: The Renewed Clinical Interest in Lysergic Acid
LSD depression treatment has moved from a decades-long research freeze into late-stage clinical trials, with a Phase 3 study of a pharmaceutical LSD formulation reporting positive...
LSD Anxiety Treatment: What Modern Clinical Trials Are Finding
Research on LSD anxiety treatment has produced some of the strongest controlled data in psychedelic medicine. A 2025 Phase 2b trial published in JAMA found that...
Complex PTSD Psychedelic Therapy: Why cPTSD Is Different from PTSD
Complex PTSD (cPTSD) differs from PTSD because it develops from prolonged, repeated trauma, and it adds lasting disturbances in emotional regulation, self-worth, and relationships on top...
MDMA Couples Therapy: When Shared Healing Requires Shared Vulnerability
MDMA couples therapy has been tested in only one published trial: a 2020 uncontrolled pilot of six couples that combined MDMA with Cognitive-Behavioural Conjoint Therapy for...
MDMA for Childhood Trauma: What the Research Shows About Healing Early Wounds
No clinical trial has yet tested MDMA-assisted therapy specifically for childhood trauma as a standalone diagnosis, so the real answer is that direct evidence does not...
LSD Therapy Guide: From Hofmann’s Discovery to Modern Clinical Use
LSD-assisted therapy uses a single high dose of lysergic acid diethylamide, given alongside structured psychological support, to treat anxiety and related conditions. Modern controlled trials, including...
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