The Best Psychedelic for Depression? Psilocybin vs Ketamine vs LSD vs Ayahuasca
There is no single best psychedelic for depression, but the evidence is not evenly distributed. Ketamine has the strongest legal access and the fastest onset, psilocybin...
LSD Alcoholism Treatment: The Forgotten Research That Started Psychedelic Therapy
Six randomized controlled trials of LSD alcoholism treatment conducted between the 1950s and 1970s, pooled in a 2012 meta-analysis of 536 participants, found that a single...
LSD Depression Treatment: The Renewed Clinical Interest in Lysergic Acid
LSD depression treatment has moved from a decades-long research freeze into late-stage clinical trials, with a Phase 3 study of a pharmaceutical LSD formulation reporting positive...
LSD Anxiety Treatment: What Modern Clinical Trials Are Finding
Research on LSD anxiety treatment has produced some of the strongest controlled data in psychedelic medicine. A 2025 Phase 2b trial published in JAMA found that...
LSD Therapy Guide: From Hofmann’s Discovery to Modern Clinical Use
LSD-assisted therapy uses a single high dose of lysergic acid diethylamide, given alongside structured psychological support, to treat anxiety and related conditions. Modern controlled trials, including...
Microdosing Protocols in 2026: Fadiman, Stamets, and the Clinical Data
The two most widely followed microdosing protocols are the Fadiman protocol (one day on, two days off) and the Stamets Stack (four or five days on,...
Microdosing Psychedelics — Promise, Risks, and Where We Go from Here
Quick answer: Microdosing psychedelics means taking very small, sub-perceptual doses of substances such as psilocybin or LSD, usually on a repeated schedule rather than in a...
LSD for Anxiety: What a Landmark Clinical Trial Actually Found
Quick answer: A LSD For Anxiety randomized, placebo-controlled Phase 2b trial published in JAMA found that a single oral dose of MM120, an investigational LSD formulation...
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