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Substance Deep-Dives

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Geo-Specific Guides

Psychedelic Therapy California 2026: What’s Legal and What’s Not

Last Updated: May 2026 Psychedelic therapy in California is a complicated picture in 2026. Ketamine is the one legally accessible option through licensed medical providers, while...

April 18, 2026 · 8 min
Conditions

Set and Setting in 2026: A Psychedelic Preparation Guide for High-Performers

Set and setting psychedelics research refers to the two core non-pharmacological factors that shape a psilocybin experience: your internal state (set) and the physical and relational...

April 17, 2026 · 9 min
Conditions

The default mode network, explained: why psychedelics reset how your brain thinks

The default mode network is a cluster of brain regions responsible for self-referential thinking, rumination, and your ongoing sense of “I.” Research on default mode network...

April 16, 2026 · 9 min
Conditions

What executives are actually using psychedelic therapy for (and what the data shows)

Psychedelic therapy for executives is moving beyond reputation and into clinical evidence. A growing number of C-suite leaders are using professionally supported psilocybin and ketamine experiences...

April 15, 2026 · 8 min
Mental Health

Psychedelics for Depression: What the 2026 Research Actually Shows

Quick Answer  Psilocybin and other psychedelics show real, measurable promise for depression, particularly treatment-resistant cases. But the evidence in 2026 is more complicated, more honest, and...

March 22, 2026 · 8 min
Integration

Microdosing Psychedelics — Promise, Risks, and Where We Go from Here

Quick answer: Microdosing psychedelics means taking very small, sub-perceptual doses of substances such as psilocybin or LSD, usually on a repeated schedule rather than in a...

March 21, 2026 · 5 min
LSD

LSD for Anxiety: What a Landmark Clinical Trial Actually Found

Quick answer: A LSD For Anxiety randomized, placebo-controlled Phase 2b trial published in JAMA found that a single oral dose of MM120, an investigational LSD formulation...

November 30, 2025 · 7 min
Legal / Policy / Geo-Legal

MDMA Therapy FDA Decision, What the Rejection Letter Means for Seekers

The FDA rejected Lykos Therapeutics’ application for MDMA-assisted therapy for PTSD, citing three specific concerns: gaps in safety reporting, insufficient evidence that benefits lasted over time,...

November 22, 2025 · 8 min
Guides

It’s Supposed To Hurt… | JourneyŌM Guides Series

Brian, a JourneyŌM guide reflects on presence, capacity, and the steady work of being human. It’s Supposed To Hurt… …at least some of the time. I’ve...

August 20, 2025 · 7 min
Guides

Ketamine Therapy Preparation: What to Expect and Why It Matters

Ketamine therapy preparation is not a formality you complete before the real thing begins. It is a functional part of what makes the treatment work. What...

August 12, 2025 · 10 min

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