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Substance Deep-Dives

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Preparation / Integration

Ketamine Therapy: A Complete Guide to Forms, Administration, and What to Expect | JourneyŌM

Ketamine therapy is delivered through several distinct routes, including intravenous infusion, intramuscular injection, FDA-approved esketamine nasal spray, and compounded sublingual or oral formulations. The route you...

July 29, 2026 · 9 min
Conditions

Ketamine Addiction Treatment: An Emerging Pathway for Alcoholism and Substance Use

Ketamine addiction treatment is supported by several small randomized trials showing improved abstinence in alcohol and cocaine use disorder, but only when the infusion is paired...

July 29, 2026 · 10 min
Conditions

Treatment-Resistant Depression and Psychedelic Therapy: How the Conversation Is Changing

Treatment-resistant depression psychedelic therapy refers to the use of compounds like psilocybin and ketamine for people whose depression has not responded to at least two standard...

July 28, 2026 · 8 min
Conditions

Ketamine PTSD Treatment: What the Clinical Evidence Shows

Ketamine PTSD treatment has produced rapid symptom relief in small controlled trials, with some participants improving within hours rather than weeks. The evidence is promising but...

July 28, 2026 · 8 min
Conditions

Ketamine for Anxiety Disorders: What the Research Shows

Ketamine anxiety treatment has shown rapid, short-lived reductions in symptoms of generalized and social anxiety disorder across several small controlled trials, often within hours of a...

July 28, 2026 · 8 min
Conditions

Ketamine for Treatment-Resistant Depression: The Fastest-Acting Antidepressant

Ketamine for treatment-resistant depression can reduce symptoms within hours rather than the four to six weeks standard antidepressants typically require, and in a single large controlled...

July 27, 2026 · 8 min
Psilocybin

Psilocybin Therapy Guide: A Complete Guide to Therapeutic Use

Psilocybin is the active compound in certain mushrooms, and in a therapeutic setting it is used in one or two carefully prepared sessions alongside professional psychological...

July 7, 2026 · 9 min
Executive

Psychedelic Guide Credentials: The Vetting Questions That Matter

Psychedelic guide credentials are not standardized across the field, which means the quality of support you receive depends heavily on who you choose and how carefully...

May 31, 2026 · 9 min
Executive

Psychedelic Therapy Screening: Are You a Candidate?

A psychedelic therapy screening assessment is the structured clinical process that determines whether you are a suitable candidate for psilocybin or similar modalities. For high-performing individuals,...

May 27, 2026 · 8 min
Legal / Policy / Geo-Legal

MDMA Therapy 2026 Update: Where Things Stand After the FDA Rejection

The FDA rejected Lykos Therapeutics’ application for MDMA-assisted therapy for PTSD in August 2024, and as of mid-2026 that decision stands. MDMA remains a Schedule I...

May 27, 2026 · 10 min

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